Combine the mayonnaise and adobo sauce and mix well. Set aside.
Making the hamburger
In a mixing bowl combine the ground beef, oregano, salt, garlic powder, and chipotle pepper together. Be sure to not overmix.
Form into 4 balls and then flatten to about a half an inch. If you want a larger burger flatten a bit more.
On medium high/indirect heat, cook the hamburgers for 3-5 minutes per side depending on preferred doneness. Place the slice of cheese on top of the burger after it has been flipped.
Assembly
Spread chipotle mayonnaise on the bottom bun and top with the burger patty. Add the avocado and any other additional toppings and spread a little more chipotle mayonnaise on the top bun.